The prefixes a- and an- indicate the absence, lack, or complete loss of something. They are commonly used in medical terminology to describe conditions where a normal function, substance, or structure is missing.
Etymology
Greek a-/an- → “not, without”; a- / an- — the Greek alpha privative, one of the oldest and most productive prefixes in medical terminology. Parallel to Latin in- (also meaning “not/without”). The suffix use derives from Latin and Greek nominative noun endings