-ones

DEFINITION of -ones

The suffix -one (pluralized as -ones) is a chemical and pharmacological designation indicating a ketone group — a carbonyl (C=O) bonded to two carbon atoms within a molecular structure. In medicine, this suffix is most prominently found in the naming of steroid-based compounds, including naturally occurring hormones and their synthetic analogs. It signals that the molecule contains or is derived from a steroid backbone with a ketone moiety. Drugs ending in -one or -ones span a wide range of therapeutic classes: corticosteroids, progestogens, androgens, opioid antagonists, and more.

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ETYMOLOGY of -ones

german -one From German Keton → French acétone → IUPAC chemical nomenclature Keton. Derived from French acide acétique (acetic acid). Introduced by August Wilhelm von Hofmann, 19th century organic chemist; Root meaning. Essentially “ketone-bearing compound”; later adopted into pharmaceutical naming conventions as a suffix signaling steroid/ketone structure

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POSSIBLE ALIASES / VARIANTS

• -one (singular form — the base suffix)
• -onum (Latin pharmaceutical form)
• -anone (variant in some ketone compound names)
• -dione (indicates two ketone groups, e.g., prednisone metabolites)
• -trione (three ketone groups)
• -sone (a contracted variant common in corticosteroid names)

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RELATED TERMS to -ones

🔵 Corticosteroids

Drug	Use
Cortisone	Anti-inflammatory, adrenal replacement
Prednisone	Immunosuppression, inflammation
Prednisolone	Ophthalmic & systemic inflammation
Triamcinolone	ENT, ophthalmic, dermatologic injection
Budesonide	Airway inflammation
Fluticasone	Asthma, allergic rhinitis

🟢 Androgens / Sex Hormones

Drug	Use
Testosterone	Androgen replacement
Progesterone	Hormonal therapy
Aldosterone	Mineralocorticoid (fluid/electrolyte balance)

🟡 Opioid Antagonists / Pain

Drug	Use
Naloxone	Opioid reversal
Naltrexone	Opioid/alcohol dependence
Methadone	Opioid dependence, pain
Oxycodone	Pain management
Hydrocodone	Pain management

🟠 Other Notable -ones

Drug	Use
Amiodarone	Cardiac arrhythmia
Ketamine	Anesthesia (ketone-related)
Acetone	Metabolic ketosis marker

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CODING AND NUANCES

RELEVANT ICD-10 CODES

(Conditions commonly associated with -one drug classes or ketone metabolism)

Code	Description
E10.10	Type 1 diabetes with ketoacidosis, without coma
E10.11	Type 1 diabetes with ketoacidosis, with coma
E11.10	Type 2 diabetes with ketoacidosis, without coma
E11.11	Type 2 diabetes with ketoacidosis, with coma
E27.1	Primary adrenocortical insufficiency (treated with cortisone/hydrocortisone)
E27.40	Corticoadrenal insufficiency, unspecified
Z79.52	Long-term (current) use of systemic steroids
T38.0X1A	Poisoning by glucocorticoids, accidental, initial encounter
E87.5	Hyperkalemia (related to aldosterone deficiency/antagonism)

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RELEVANT CPT CODES

(Procedures/administrations involving -one class drugs)

Code	Description
96372	Therapeutic injection, subcutaneous or IM (e.g., testosterone, triamcinolone)
96401	Chemotherapy injection, non-hormonal (some -one agents)
96402	Chemotherapy injection, hormonal antineoplastic
20610	Arthrocentesis/injection, major joint (often triamcinolone)
67028	Intravitreal injection (e.g., triamcinolone — relevant to your Ophthalmology specialty)

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Coder’s Note: When coding for long-term corticosteroid (-one drug) use, always check for Z79.52 as an additional diagnosis. In your Urology/Ophthalmology/ENT specialties, watch for triamcinolone injections (intravitreal, sinus, or joint) and verify the route and drug to assign the correct administration CPT. For ICD-10 codes involving ketoacidosis, ensure the diabetes type and complication specificity are captured for full 7-character codes where applicable.

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DERIVATIONS of -ones

TABLE definition AS Definition 
WHERE length(filter(roots, (word) => econtains([[]].roots, word))) > 0 AND file.name !=[[]].file.name
SORT file.name ASC

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Query

TABLE definition AS Definition
FROM #medroot
WHERE length(filter(definition, (word) => econtains([[]].definition, word))) > 0 AND file.name != [[]].file.name

Med roots dictionary Appendix A Prefixes Appendix B Combining Forms Appendix C Suffixes Appendix D Suffix forms