Keratitis is an inflammatory condition of the cornea — the clear, dome-shaped front surface of the eye — that can involve the epithelium, stroma, or endothelium depending on the type and causative agent. It may be infectious (bacterial, viral, fungal, or parasitic) or non-infectious (autoimmune, exposure-related, UV-induced, or neurotrophic). Symptoms typically include eye pain, photophobia, tearing, blurred vision, and a foreign-body sensation. Severe or untreated keratitis can progress to corneal ulceration, scarring, perforation, and permanent vision loss. It is one of the leading causes of preventable corneal blindness worldwide.
greek “Keratitis” derives from the Greek keras (κέρας), meaning “horn” — a reference to the horn-like transparency and hardness of the cornea. The suffix -itis is from Greek -itis, meaning “inflammation of.” Together: “inflammation of the cornea.” The kerat- root appears throughout ophthalmologic terminology wherever the cornea is involved.
ICD-10-CM CODES — Category H16
All codes below require a final digit specifying laterality: 1 = right eye, 2 = left eye, 3 = bilateral, 9 = unspecified eye.
Other/UnspecifiedH16.8 — Other keratitis H16.9 — Unspecified keratitis
RELEVANT CPT CODES
65430 — Scraping of cornea for smear and/or culture
65435 — Removal of corneal epithelium (chemical or physical means), with or without chemocauterization
65600 — Multiple punctures of anterior cornea (e.g., for recurrent erosion or superficial keratitis)
65710 — Keratoplasty (corneal transplant) — lamellar
65730 — Keratoplasty — penetrating, except in aphakia or pseudophakia
65750 — Keratoplasty — penetrating, in aphakia65755 — Keratoplasty — penetrating, in pseudophakia65756 — Endothelial keratoplasty (DSEK/DMEK)
65771 — Radial keratotomy
92025 — Corneal topography
92285 — External ocular photography (to document corneal findings)
💡 CODING TIPS
When the physician documents herpetic keratitis, verify whether it is HSV (herpes simplex) or HZV (herpes zoster) — both require an additional code from the B00.x or B02.x series as the underlying cause, and the keratitis code is sequenced as an additional diagnosis. For example, HSV keratoconjunctivitis would pair B00.52 with the appropriate H16.2xx code. Similarly, acanthamoeba keratitis should be coded with B60.13 as the primary causative organism. Corneal ulcer with hypopyon (H16.03x) is a red flag for aggressive infection and often warrants concurrent culture codes. Always check laterality — unspecified eye (x9) should only be used when the record genuinely does not specify.