“split,” “cleft,” “fissure” — condition-denoting suffix or combining form referring to splitting, cleft, or division
The word entered English in the 1870s as schistosoma (noun), borrowed from Modern Latin schistosoma, from Greek σχῖσις (skhisis) — literally “a splitting” (from skhizein “to split”). The term schizophrenia was coined in the 1910s by Eugen Bleuler. The root skhizein (“to split”) connects -schisis to the entire division and cleft roots: schizophrenia (schizo- + phren + -ia → split mind), myeloschisis (myelo- + schisis → splitting of the spinal cord), and schistosomiasis (schisto- + soma + -iasis → disease caused by the split-body worm). The condition-denoting suffix/combining form-schisis is productive in neurosurgery, psychiatry, and parasitology: e.g., encephaloschisis, meningoschisis, labioschisis, urethroschisis, and schizocytosis.