N28.86 - Ureteritis Cystica

Short Description

N28.86: Use for ureteritis cystica - a rare, typically benign condition characterized by the formation of multiple small, fluid-filled cysts within the walls of the ureter. These submucosal cysts develop due to chronic inflammation, most commonly from recurrent urinary tract infections, chronic irritation, urinary stones, or long-term catheterization.


Full Description & Clinical Context

N28.86 - Ureteritis cystica describes a non-neoplastic lesion of the ureter characterized by multiple submucosal small cysts in the ureteral wall, caused by inflammation from urinary tract stones or infection.

Key Clinical Features:

  • Rare condition - uncommon diagnosis
  • Cystic changes - multiple small fluid-filled cysts in ureter wall
  • Benign nature - not cancerous, but requires monitoring
  • Inflammatory origin - develops from chronic irritation/infection
  • Usually asymptomatic - often incidental finding on imaging
  • Submucosal location - cysts form beneath the mucosal lining

Pathophysiology: Ureteritis cystica develops when chronic inflammation of the ureteral mucosa leads to the formation of small cystic spaces within the ureteral wall. The exact mechanism is not fully understood, but it is believed to involve:

  • Chronic irritation from infection, stones, or obstruction
  • Inflammatory changes in the ureteral lining
  • Formation of submucosal cysts (von Brunn’s nests become cystic)
  • Cysts filled with clear fluid
  • Can occur anywhere along the ureter
  • Usually bilateral but can be unilateral

Common causes/risk factors:

  • Chronic urinary tract infections (UTIs) - most common association
  • Long-term catheterization - chronic irritation
  • Ureteral obstructions - from stones, strictures, tumors
  • History of kidney stones - chronic stone passage
  • Recurrent pyelonephritis
  • Chronic instrumentation of urinary tract

Clinical significance:

  • Usually benign and asymptomatic
  • Rarely causes significant obstruction
  • Can mimic other ureteral pathology on imaging
  • Important to distinguish from urothelial carcinoma
  • May be found incidentally during imaging for other reasons
  • Generally has good prognosis with monitoring

Common symptoms (if present):

  • Often asymptomatic (most common presentation)
  • Occasional hematuria (blood in urine) - microscopic or gross
  • Flank pain (rarely)
  • Urinary tract infection symptoms (if concurrent infection)
  • Renal colic (if obstruction occurs)

Code Details

  • Code set: ICD-10-CM
  • Full code: N28.86
  • Title: Ureteritis cystica
  • Code type: Billable/specific diagnosis code
  • Clinical category: Other disorders of kidney and ureter, not elsewhere classified
  • Parent code: N28.8 (Other specified disorders of kidney and ureter)
  • Grandparent code: N28 (Other disorders of kidney and ureter, not elsewhere classified)
  • ICD-9-CM equivalent: 590.3 - Pyeloureteritis cystica (approximate mapping)

Coding notes from N28.8 (parent):

  • Excludes1:
    • Hydroureter → N13.4
    • Ureteric stricture with hydronephrosis → N13.1
    • Ureteric stricture without hydronephrosis → N13.5

Approximate synonyms/terms:

  • Infective ureteritis
  • Ureteritis (when cystic type)

Clinical classification:

  • CCSR Category Code: GEN006
  • Category: Other specified and unspecified diseases of kidney and ureters
  • Inpatient Default CCSR: Yes
  • Outpatient Default CCSR: Yes

The N28 family includes THREE distinct cystic conditions:

CodeConditionLocationKey Feature
N28.84Pyelitis cysticaRenal pelvis onlyCysts in renal pelvis
N28.85Pyeloureteritis cysticaRenal pelvis + ureterCysts in BOTH locations
N28.86Ureteritis cysticaUreter onlyCysts in ureter ONLY ← YOU ARE HERE

Critical coding distinction:

  • N28.84 = Renal pelvis ONLY
  • N28.85 = Renal pelvis AND ureter (both involved)
  • N28.86 = Ureter ONLY
  • Documentation must specify location to determine correct code

Note: ICD-9-CM 590.3 (Pyeloureteritis cystica) maps to N28.85, but N28.86 is more specific for ureter-only involvement.


Complete N28 Family - Other Kidney/Ureter Disorders

CodeDescriptionKey Feature
N28.0Ischemia and infarction of kidneyBlood flow compromise
N28.1Cyst of kidney, acquiredAcquired kidney cyst
N28.8-Other specified disordersParent category
N28.81Hypertrophy of kidneyKidney enlargement
N28.82MegaloureterDilated ureter
N28.83NephroptosisDropped/mobile kidney
N28.84Pyelitis cysticaCysts in renal pelvis
N28.85Pyeloureteritis cysticaCysts in pelvis + ureter
N28.86Ureteritis cysticaCysts in ureter ← YOU ARE HERE
N28.89Other specified disordersOther
N28.9Disorder of kidney and ureter, unspecifiedUnspecified

When to Use N28.86

Use N28.86 ONLY when:

  1. Ureteritis cystica documented:

    • Explicit diagnosis of “ureteritis cystica” OR
    • Imaging/pathology report describes cystic changes in ureter wall
    • Biopsy confirms cystic ureteritis
  2. Location is ureter ONLY:

    • Cysts involve ureter, NOT renal pelvis
    • If both renal pelvis and ureter involved → use N28.85
    • If only renal pelvis involved → use N28.84
  3. Not excluded conditions:

    • NOT hydroureter (N13.4)
    • NOT ureteric stricture (N13.1 or N13.5)
    • NOT ureteral tumor/neoplasm (code as neoplasm)
  4. Appropriate clinical context:

    • History of recurrent UTIs, stones, or chronic irritation
    • Imaging shows characteristic cystic changes
    • Benign process confirmed

Typical scenarios for N28.86:

  • “CT urogram shows multiple small cysts in the ureteral wall consistent with ureteritis cystica”
  • “Ureteroscopy reveals cystic changes in distal ureter; biopsy confirms ureteritis cystica”
  • “Incidental finding of ureteritis cystica on imaging for kidney stones”

When NOT to Use N28.86

Do NOT use N28.86 when:

ScenarioUse InsteadWhy
Cysts in renal pelvis onlyN28.84 (Pyelitis cystica)Different location
Cysts in BOTH pelvis and ureterN28.85 (Pyeloureteritis cystica)Both locations involved
HydroureterN13.4Dilated ureter from obstruction
Ureteric strictureN13.1 or N13.5Narrowing/stricture
Urothelial carcinomaC66.x (malignancy) or D41.2x (benign)Neoplasm, not cystic condition
Simple ureteritis (non-cystic)N28.89Inflammation without cysts
MegaloureterN28.82Dilated ureter

Critical distinction:

  • Ureteritis cystica (N28.86) = benign cystic changes
  • Urothelial carcinoma can mimic ureteritis cystica on imaging → biopsy may be needed

Documentation Requirements for N28.86

MINIMUM documentation needed to assign N28.86:

MUST include:

  1. “Ureteritis cystica” documented OR imaging/pathology describes cystic changes in ureter:

    • Provider diagnosis, radiology report, or pathology report
    • Cystic lesions in ureter wall
  2. Location specified as URETER (not renal pelvis):

    • Cysts in ureter only
    • If renal pelvis involved too → N28.85
    • If only renal pelvis → N28.84
  3. Benign process:

    • Not malignancy
    • May need biopsy to confirm benign nature

CANNOT use if:

  • Only renal pelvis involved (use N28.84)
  • Both renal pelvis and ureter involved (use N28.85)
  • Urothelial carcinoma diagnosed (code as neoplasm)
  • Simple hydroureter without cystic changes (use N13.4)

SHOULD document (best practice):

  • Location (which ureter: right, left, or bilateral)
  • Extent (proximal, mid, distal ureter)
  • Size and number of cysts (if visible on imaging)
  • Associated findings (hydronephrosis, stones, stricture)
  • Underlying cause (chronic UTI, stones, catheterization)
  • Diagnostic method (CT, MRI, ureteroscopy, biopsy)
  • Whether symptomatic or incidental finding
  • Treatment plan (observation vs intervention)

Clinical Evaluation

Typical workup when ureteritis cystica suspected or diagnosed:

History:

  • History of recurrent UTIs
  • History of kidney stones
  • Prior urologic instrumentation or surgery
  • Long-term catheterization history
  • Symptoms (hematuria, flank pain, or asymptomatic)
  • Duration of symptoms

Physical examination:

  • Usually normal
  • Costovertebral angle tenderness (if concurrent infection)
  • Abdominal/flank examination

Diagnostic studies:

Imaging (diagnostic):

  • CT Urography (gold standard):

    • Multiple small filling defects in ureter
    • Submucosal cystic lesions
    • Characteristic “cobblestone” or “beaded” appearance
    • Rules out obstruction, stones, masses
    • Can distinguish from tumor
  • Intravenous Pyelogram (IVP):

    • Multiple small filling defects
    • “Halo” or “ring” sign around cysts
    • Less commonly used now (CT preferred)
  • Retrograde Pyelogram:

    • If CT contraindicated
    • Direct visualization of ureter
    • Shows filling defects
  • Renal/ureteral ultrasound:

    • May show ureteral wall thickening
    • Less specific than CT
    • Good for follow-up
  • MRI abdomen/pelvis:

    • Alternative to CT (no radiation)
    • Shows cystic lesions
    • Good soft tissue detail

Ureteroscopy with biopsy (confirmatory):

  • Direct visualization of ureter
  • Biopsy of lesions to confirm benign nature
  • Rule out urothelial carcinoma
  • Therapeutic if obstructive

Laboratory:

  • Urinalysis:

    • Hematuria (microscopic or gross)
    • Pyuria (if infection present)
    • Bacteriuria
  • Urine culture:

    • If infection suspected
    • Guide antibiotic therapy
  • Urine cytology:

    • Rule out malignancy if concern
    • Usually negative in ureteritis cystica
  • BMP/CMP:

    • Renal function (creatinine, eGFR)
    • Especially if obstruction present

Histopathology (if biopsy performed):

  • Multiple submucosal cysts
  • Cysts lined by transitional or cuboidal epithelium
  • Chronic inflammatory changes
  • No dysplasia or malignancy

Management

Treatment depends on symptoms and associated findings:

Observation (most common approach):

  • If asymptomatic and incidental finding
  • No obstruction or significant complications
  • Regular monitoring with imaging
  • Follow-up every 6-12 months initially
  • Patient education

Treatment of underlying cause:

  • Treat chronic UTIs:

    • Antibiotics for active infection
    • Prophylactic antibiotics if recurrent
    • Address underlying risk factors
  • Remove/treat stones:

    • Stone removal if causing chronic irritation
    • Medical expulsive therapy
    • Lithotripsy or ureteroscopy
  • Remove/change catheters:

    • If long-term catheterization contributing
    • Consider alternatives (intermittent catheterization)

Medical management:

  • Antibiotics: For associated UTIs
  • Pain management: NSAIDs or analgesics if symptomatic
  • Increased hydration: Prevent stone formation, flush urinary tract

Surgical intervention (rare):

  • Indications:

    • Significant ureteral obstruction
    • Recurrent infections despite medical management
    • Uncertainty about malignancy
    • Severe symptoms
  • Options:

    • Ureteroscopic resection/ablation of cysts
    • Ureteral stent placement (if obstruction)
    • Partial ureterectomy (very rare, if extensive)
    • Ureteroureterostomy (if segmental involvement)

Monitoring:

  • Periodic imaging (ultrasound or CT)
  • Urinalysis for hematuria and infection
  • Renal function monitoring
  • Watch for development of obstruction
  • Rule out progression (extremely rare to malignancy)

Prognosis:

  • Usually benign course
  • Good prognosis with monitoring
  • Rarely causes significant complications
  • Most patients remain asymptomatic
  • Very rare progression to malignancy (though extremely uncommon)
  • Can resolve spontaneously if underlying cause addressed

Complications

Potential complications (rare):

  • Urinary obstruction - cysts can rarely cause partial obstruction
  • Recurrent UTIs - chronic inflammation predisposes to infection
  • Hydronephrosis - if significant obstruction develops
  • Hematuria - microscopic or gross blood in urine
  • Ureteral stricture - chronic inflammation can lead to scarring
  • Extremely rare malignant transformation (case reports only)

When to seek professional help:

  • Persistent or severe flank pain
  • Noticeable blood in urine (gross hematuria)
  • Frequent or painful urination
  • Fever (suggests infection)
  • Decreased urine output

HCC Information

  • N28.86 does NOT map to a CMS-HCC - benign ureteral condition not risk-adjusted
  • No direct HCC weight or RAF score impact
  • Used for accurate diagnosis documentation and follow-up

Note: If ureteritis cystica leads to chronic kidney disease (N18.x) or other complications, those conditions may have HCC implications, but N28.86 itself does not.


RVU / wRVU Information

  • ICD-10-CM codes (including N28.86) do NOT carry RVUs or wRVUs
  • RVUs apply to CPT/HCPCS procedure codes only
  • N28.86 supports medical necessity for:
    • Imaging studies (CT urography, ultrasound, MRI)
    • Ureteroscopy
    • Ureteral procedures
    • Follow-up monitoring

Common CPT Procedure Pairings with N28.86

E/M Services:

Imaging:

  • 74150-74170 - CT abdomen (without/with contrast)
  • 74176-74178 - CT abdomen and pelvis
  • 74400-74410 - Urography (intravenous pyelogram)
  • 74425 - Urography, antegrade
  • 76770 - Ultrasound, retroperitoneal (includes kidney/ureter)
  • 76775 - Ultrasound, retroperitoneal, limited
  • 74181-74183 - MRI abdomen

Ureteroscopy and Procedures:

  • 52000 - Cystourethroscopy (diagnostic)
  • 52005 - Cystourethroscopy, with ureteral catheterization
  • 52007 - Cystourethroscopy, with brush biopsy of ureter and/or renal pelvis
  • 52204 - Cystourethroscopy, with biopsy
  • 52320-52325 - Cystourethroscopy, with removal of calculus
  • 52332 - Cystourethroscopy, with insertion of ureteral stent
  • 52341-52346 - Cystourethroscopy with ureteroscopy
  • 52352-52355 - Cystourethroscopy with ureteroscopy and biopsy

Ureteral Catheterization:

  • C1758 - Catheter, ureteral (HCPCS)
  • 52005 - Cystourethroscopy with ureteral catheterization

Other Procedures (if complications/extensive disease):

Laboratory:

  • 81001 - Urinalysis, automated with microscopy
  • 87086 - Urine culture
  • 88305 - Surgical pathology, biopsy (ureter)

Common Associated ICD-10-CM Codes

Often coded WITH N28.86:

Related ureter/kidney conditions:

Associated infections:

  • N30.x - Cystitis (bladder infection)
  • N30.81/N30.91 - Other/unspecified cystitis with hematuria
  • N39.0 - Urinary tract infection, site not specified
  • N10 - Acute pyelonephritis (kidney infection)
  • N12 - Tubulo-interstitial nephritis

Associated symptoms:

  • R31.0 - Gross hematuria (if visible blood)
  • R31.21/R31.29 - Microscopic hematuria
  • R10.x - Abdominal pain (if symptomatic)
  • N23 - Unspecified renal colic (if pain present)

Risk factors/causes:

  • Z87.440 - Personal history of urinary tract infections
  • Z90.5 - Acquired absence of kidney (if contralateral kidney removed)

Clinical Examples: When to Use N28.86

✅ Example 1 - Incidental Finding on CT for Kidney Stones

SCENARIO:
55-year-old male with history of recurrent kidney stones presents
with right flank pain. CT urogram ordered.

CT Urogram Report:
- Small non-obstructing stone in right renal pelvis (4 mm)
- Incidental finding: Multiple small submucosal cystic lesions 
  in the right ureter consistent with ureteritis cystica
- No hydronephrosis
- Left kidney and ureter normal

Assessment:
- Right ureteral calculus, non-obstructing
- Ureteritis cystica, right ureter (incidental finding)

Plan:
- Medical expulsive therapy for stone
- Follow-up imaging in 3 months
- Monitor for obstruction or symptoms from ureteritis cystica
- Treat underlying cause (stone disease)

CODES:
- N20.1 (Calculus of ureter) - PRIMARY (symptomatic)
- N28.86 (Ureteritis cystica) - SECONDARY (incidental)

RATIONALE:
├─ Ureteritis cystica documented on CT
├─ Location: ureter ONLY (not renal pelvis)
├─ N28.86 appropriate for ureter-only involvement
├─ Stone is primary reason for encounter
└─ Ureteritis cystica is secondary/incidental finding

✅ Example 2 - Ureteroscopy with Biopsy Confirming Diagnosis

SCENARIO:
62-year-old female with recurrent UTIs and intermittent hematuria.
Imaging shows ureteral lesions concerning for possible tumor.
Ureteroscopy performed.

Ureteroscopy Findings:
- Multiple small cystic lesions in left distal ureter
- "Cobblestone" appearance of ureteral mucosa
- No solid masses visualized
- Biopsy performed

Pathology:
- Ureteritis cystica
- Multiple submucosal cysts lined by benign urothelium
- Chronic inflammatory changes
- No dysplasia or malignancy

Assessment:
- Ureteritis cystica, left ureter, confirmed by biopsy
- History of recurrent UTIs (likely causative)

Plan:
- Prophylactic antibiotics for recurrent UTI prevention
- Follow-up imaging in 6 months
- Monitor for hematuria

CODES:
- N28.86 (Ureteritis cystica) - PRIMARY
- Z87.440 (Personal history of urinary tract infections)
- R31.29 (Other microscopic hematuria) if still present

RATIONALE:
├─ Ureteritis cystica confirmed by pathology
├─ Location: left ureter only
├─ Benign process confirmed (not malignancy)
├─ N28.86 is correct code for ureter-only involvement
└─ History of UTIs likely contributory

✅ Example 3 - Bilateral Ureteritis Cystica

SCENARIO:
48-year-old male with history of long-term indwelling urinary catheter
(neurogenic bladder from spinal cord injury). Follow-up imaging.

Imaging:
- CT urogram: Bilateral small cystic lesions throughout both ureters
- No involvement of renal pelvis noted
- Mild bilateral hydroureter

Assessment:
- Ureteritis cystica, bilateral ureters
- Likely secondary to chronic catheterization
- Neurogenic bladder due to spinal cord injury

Plan:
- Consider changing to clean intermittent catheterization
- Monitor with serial imaging
- Urology follow-up

CODES:
- N28.86 (Ureteritis cystica) - can use even for bilateral
- N31.2 (Flaccid neuropathic bladder) - underlying condition
- G82.20 (Paraplegia, unspecified) - cause of neurogenic bladder
- N13.4 (Hydroureter) if significant dilation

RATIONALE:
├─ Ureteritis cystica involving BOTH ureters
├─ N28.86 appropriate (ureters only, not renal pelvis)
├─ Code underlying neurogenic bladder also
├─ Chronic catheterization is likely causative
└─ Bilateral still coded as N28.86 (no laterality in code)

❌ Example 4 - WRONG: Both Renal Pelvis and Ureter Involved

SCENARIO:
Patient with chronic pyelonephritis.

Imaging: Cystic lesions in BOTH renal pelvis and ureter

WRONG CODE: N28.86 (ureter only)
CORRECT CODE: N28.85 (Pyeloureteritis cystica)

WHY:
├─ N28.86 is for URETER ONLY
├─ When BOTH renal pelvis AND ureter involved → N28.85
├─ N28.85 = pyeloureteritis (pelvis + ureter)
├─ Different code required for combined involvement
└─ Documentation must specify all locations involved

KEY POINT: Check imaging - pelvis involved? → N28.85

❌ Example 5 - WRONG: Only Renal Pelvis Involved

SCENARIO:
CT shows cystic changes in renal pelvis only, ureter normal.

WRONG CODE: N28.86
CORRECT CODE: N28.84 (Pyelitis cystica)

WHY:
├─ N28.86 is for URETER involvement
├─ Renal pelvis ONLY = N28.84 (pyelitis cystica)
├─ Different anatomic location = different code
├─ Must match code to documented location
└─ Renal pelvis ≠ ureter

KEY POINT: Location determines code!
Pelvis only → N28.84
Ureter only → N28.86
Both → N28.85

❌ Example 6 - WRONG: Urothelial Carcinoma, Not Cystic Condition

SCENARIO:
Imaging suspicious for ureteritis cystica.
Ureteroscopy with biopsy performed.

Pathology: High-grade urothelial carcinoma

WRONG CODE: N28.86 (ureteritis cystica)
CORRECT CODE: C66.x (Malignant neoplasm of ureter, specify laterality)

WHY:
├─ Initial imaging suggested ureteritis cystica
├─ Biopsy revealed MALIGNANCY
├─ Malignancy takes precedence over benign diagnosis
├─ Must code based on final pathology
└─ Urothelial cancer ≠ ureteritis cystica

KEY POINT: Biopsy is gold standard!
Always code based on confirmed pathology.
Cancer can mimic benign cystic conditions.

Common Documentation Errors to AVOID

❌ Error 1: Not Specifying Location (Renal Pelvis vs Ureter)

WRONG: Documentation only says "cystic changes in collecting system"
├─ Need to specify: renal pelvis, ureter, or both
├─ Different codes for different locations
└─ CORRECT: Specify exact anatomic location

✅ CORRECT: "Ureteritis cystica in right ureter" OR
           "Pyeloureteritis cystica involving pelvis and ureter"

❌ Error 2: Using N28.86 for Combined Pelvis and Ureter Involvement

WRONG: Coding N28.86 when both renal pelvis and ureter have cysts
├─ N28.86 is for URETER ONLY
├─ Both locations = N28.85 (pyeloureteritis cystica)
└─ CORRECT: Use N28.85 when both involved

✅ CORRECT: Check imaging - both locations? → N28.85

❌ Error 3: Confusing with Hydroureter or Megaloureter

WRONG: Using N28.86 for simple ureteral dilation
├─ Ureteritis cystica = cystic lesions in wall
├─ Hydroureter (N13.4) = dilated ureter from obstruction
├─ Megaloureter (N28.82) = abnormally dilated ureter
└─ CORRECT: Different pathology, different codes

✅ CORRECT: Ureteritis cystica = cysts in wall, not simple dilation

❌ Error 4: Not Ruling Out Malignancy

WRONG: Coding N28.86 based on imaging alone without tissue diagnosis
├─ Imaging can be misleading
├─ Urothelial carcinoma can mimic ureteritis cystica
├─ Biopsy may be needed for definitive diagnosis
└─ CORRECT: Code based on confirmed diagnosis

✅ CORRECT: Consider biopsy if diagnostic uncertainty
Code based on pathology when available

❌ Error 5: Not Documenting Underlying Cause

WRONG: Coding only N28.86 without associated conditions
├─ Should document risk factors (UTIs, stones, catheter)
├─ Helps establish causation
└─ CORRECT: Document underlying/contributing factors

✅ CORRECT: N28.86 + underlying cause codes
(Z87.440 for history of UTIs, N20.x for stones, etc.)

Compliance Checklist

Before coding N28.86, verify:

  • Ureteritis cystica documented (provider diagnosis or imaging report)
  • Location specified as URETER (not renal pelvis alone)
  • If renal pelvis also involved → use N28.85, not N28.86
  • If only renal pelvis → use N28.84, not N28.86
  • Is NOT hydroureter (simple dilation)
  • Is NOT ureteric stricture
  • Is NOT urothelial carcinoma (rule out malignancy)
  • Imaging report describes cystic lesions in ureter wall
  • Biopsy performed if diagnostic uncertainty
  • Document laterality (right, left, or bilateral) in clinical notes
  • Consider underlying cause codes (UTI history, stones, etc.)

Quick Reference Card

ICD-10-CM N28.86 - Ureteritis Cystica
━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━
USE WHEN:
• Ureteritis cystica documented (imaging or pathology)
• Multiple small cysts in URETER WALL only
• Benign cystic condition (not malignancy)
• Usually from chronic UTIs, stones, or catheterization
• Typically asymptomatic, incidental finding
 
DON'T USE WHEN:
• Only renal pelvis involved → N28.84 (Pyelitis cystica)
• Both pelvis AND ureter → N28.85 (Pyeloureteritis cystica)
• Hydroureter (simple dilation) → N13.4
• Ureteric stricture → N13.1 or N13.5
• Urothelial carcinoma → C66.x (malignancy)
 
CRITICAL LOCATION DISTINCTION:
• N28.84 = Renal pelvis ONLY (pyelitis cystica)
• N28.85 = Pelvis AND ureter (pyeloureteritis cystica)
• N28.86 = URETER ONLY (ureteritis cystica) ← YOU ARE HERE
• Documentation must specify location!
 
RARE CONDITION:
• Uncommon diagnosis
• Usually benign and asymptomatic
• Good prognosis with monitoring
• May need biopsy to rule out malignancy
 
IMAGING:
• CT urography - gold standard
• Shows "cobblestone" or "beaded" appearance
• Multiple small filling defects in ureter
• Submucosal cystic lesions
 
COMMON CAUSES:
• Chronic/recurrent UTIs (most common)
• Kidney stones (chronic irritation)
• Long-term catheterization
• Chronic ureteral obstruction
 
MANAGEMENT:
• Usually observation if asymptomatic
• Treat underlying cause (UTIs, stones)
• Monitor with serial imaging
• Surgery rarely needed
 
NOT HCC:
• No direct HCC mapping
• Benign condition
 
ICD-9 EQUIVALENT:
• 590.3 - Pyeloureteritis cystica (approximate)
 
BOTTOM LINE:
N28.86 = cystic lesions in URETER ONLY (not renal pelvis).
If pelvis also involved → use N28.85. Rare, benign condition
from chronic inflammation. Usually asymptomatic. Monitor.

Last Updated: February 9, 2026
For coding reference only - always verify against the current ICD-10-CM, official guidelines, payer policies, and facility rules.
Key concept: N28.86 is for ureteritis cystica - multiple small cysts in the ureter wall only. Critical distinction: N28.84 (renal pelvis only), N28.85 (both pelvis and ureter), N28.86 (ureter only). Location determines the correct code. This is a rare, typically benign condition from chronic inflammation (UTIs, stones, catheterization). Usually asymptomatic and found incidentally on imaging. May require biopsy to distinguish from urothelial carcinoma. Good prognosis with observation and treatment of underlying cause.