Dysuria describes any discomfort associated with the act of urination — most commonly a burning or stinging sensation as urine passes through the urethra, though it can also manifest as pain in the lower abdomen, suprapubic region, flank, or perineum. Pathophysiologically, it occurs when urine contacts an inflamed or irritated urethral mucosal lining; detrusor muscle contractions and urethral peristalsis during voiding then stimulate submucosal pain and sensory receptors, producing the burning sensation. Dysuria is not a diagnosis in itself but a symptom pointing to an underlying condition. It is one of a cluster of lower urinary tract symptoms (LUTS) alongside urinary frequency, urgency, and nocturia. It can occur in any age or sex, though it is statistically more common in women due to their shorter urethra increasing susceptibility to infection. Clinically, it is evaluated by targeted history, urinalysis, urine culture, and sometimes STI panels or imaging.